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Question
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Which of the following enzyme is responsible for clopidogrel resistance due to poor metabolism?
Explanation
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Clopidogrel resistance occurs due to poor metabolizers of CYP2C19, especially alleles 2 and 3
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Reference
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Chan, A., Pirmohamed, M. & Comabella, M. Pharmacogenomics in neurology Current state and future steps. Annals of Neurology 70, 684697 (2011).
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Option 1
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Is Correct (Option 1):
CYP3A5
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Option 2
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Is Correct (Option 2):
CYP2C19
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Option 3
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Is Correct (Option 3):
CYP2C9
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Option 4
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Is Correct (Option 4):
CYP2C2
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