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A 45-year-old woman with a history of migraine headaches with aura and cognitive difficulties developed a transient episode of right hemiparesis that resolved in 15 minutes <br><br>Neurologic examination reveals difficulties with attention and a spastic gait<br>She has family history of migraine and dementia in her mother and ischemic stroke in her brother <br>An MRI examination reveals symmetric increase in T2 signal in the subcortical white matter, including the temporal pole and the external capsule<br>These findings are suggestive of a mutation affecting which of the following genes?
Explanation
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Patient has autosomal dominant disorder, migraine, TIA and leukodystrophy suggestive of CADASIL, caused by NOTCH3 mutation
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Reference
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Patient has autosomal dominant disorder, migraine, TIA and leukodystrophy suggestive of CADASIL, caused by NOTCH3 mutation
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Option 1
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Is Correct (Option 1):
CLCNA1
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Option 2
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Is Correct (Option 2):
GLA gene
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Option 3
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Is Correct (Option 3):
NOTCH3
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Option 4
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Is Correct (Option 4):
Mitochondrial transfer RNA
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