Quiz Form

Question Date: 16/10/2023

Question: In dermatomyositis, which of these muscle specific antibodies is associated with risk of cancer?

Options:

• Anti Mi-2
• Melanoma differentiation protein-5 (MDA5)
• Nuclear matrix protein 2 (NXP-2)
• Transcriptional intermediary factor 1- (TIF 1-)

Correct Answer: Transcriptional intermediary factor 1- (TIF 1-)

Explaination: Several myositis specific antibodies have been identified and each has its significance. Anti Mi-2 antibody is seen in classical dermatomyositis and is associated with steroid responsiveness and good prognosis. Cancer and ILD are uncommon. Patients with Anti MDA-5 may have skin involvement without myopathy (Clinically amyopathic dermatomyositis -CADM). They may develop rapidly progressive interstitial lung disease that is resistant to treatment. Anti TIF 1- is associated strongly with malignancy in adult dermatomyositis. The association of NXP-2 antibody with calcinosis and malignancy is variable. Anti SAE is associated with typical dermatomyositis

Reference: Satoh M et al. A comprehensive overview on Myositis specific antibodies New and old biomarkers in idiopathic inflammatory myopathy. Clin Rev Allergy Immunol.201752(1)1-19.