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Question
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In dermatomyositis, which of these muscle specific antibodies is associated with risk of cancer?
Explanation
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Several myositis specific antibodies have been identified and each has its significance. Anti Mi-2 antibody is seen in classical dermatomyositis and is associated with steroid responsiveness and good prognosis. Cancer and ILD are uncommon. Patients with Anti MDA-5 may have skin involvement without myopathy (Clinically amyopathic dermatomyositis -CADM). They may develop rapidly progressive interstitial lung disease that is resistant to treatment. Anti TIF 1- is associated strongly with malignancy in adult dermatomyositis. The association of NXP-2 antibody with calcinosis and malignancy is variable. Anti SAE is associated with typical dermatomyositis
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Reference
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Satoh M et al. A comprehensive overview on Myositis specific antibodies New and old biomarkers in idiopathic inflammatory myopathy. Clin Rev Allergy Immunol.201752(1)1-19.
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Option 1
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Is Correct (Option 1):
Anti Mi-2
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Option 2
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Is Correct (Option 2):
Melanoma differentiation protein-5 (MDA5)
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Option 3
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Is Correct (Option 3):
Nuclear matrix protein 2 (NXP-2)
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Option 4
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Is Correct (Option 4):
Transcriptional intermediary factor 1- (TIF 1-)
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