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Question
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The commonest pathological substrate in surgical series of refractory epilepsy in children is..
Explanation
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Refractory epilepsy disabling seizures despite appropriate trial of two antiepileptic drugs either in combination or alone<br>FCD is the commonest cause for DRE in children over all and in surgical series<br>In developing countries like India the etiology differs from western literature, Adverse peri-natal events (48%) and CNS infection sequalae (24%) were major causes (Chawla et al)<br>Hippocampal sclerosis is commonest etiology in adults with refractory epilepsy undergoing surgery
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Reference
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J. Engel Ann Indian Acad Neurol.2014 Mar17Indian J Pediatr Oct 2014, 81(10)
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Option 1
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Is Correct (Option 1):
Hippocampal Sclerosis
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Option 2
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Is Correct (Option 2):
Gliosis
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Option 3
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Is Correct (Option 3):
Low grade tumors
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Option 4
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Is Correct (Option 4):
Focal cortical dysplasia
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