Quiz Form

Question Date: 24/11/2023

Question: All of the below statements are true for Lennox-Gastaut Syndrome except..?

Options:

• Diffuse, slow spike-wave (SSW) complexes at <3Hz, occur during wakefulness
• Myoclonic seizures associated with falls are diagnostic feature of LGS
• Paroxysmal fast rhythms (10-20 Hz) during sleep are hallmark of tonic seizures
• Non-convulsive status epilepticus is an important risk factor for cognitive impairment

Correct Answer: Myoclonic seizures associated with falls are diagnostic feature of LGS

Explaination: Myoclonic seizures: occur in 11-28% of patients and can lead to falls, but are associated with many generalized epilepsies and are therefore not regarded as a defining feature of LGS<br>Clinically characterized by multiple seizure types, Tonic seizures during sleep is the diagnostic feature<br>Abnormal EEG features of diagnostic significance include an interictal pattern of diffuse, slow spike-wave (SSW) complexes at <3Hz, occurring during wakefulness<br>Paroxysmal fast rhythms (10-20 Hz) during sleep, mainly during non-rapid eye movement sleep are the hallmark of tonic seizures

Reference: Blaise et al. Lennox-Gastaut Syndrome: A concensus approach to differential diagnosis. Epilepsia Oct 2014