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Question
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Which of the following medications slows the metabolism of dopamine in the central nervous system?
Explanation
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Entacapone is a catechol-O-methyl transferase inhibitor, which is one of the main enzymes responsible for the breakdown of dopamine in the central nervous system. The other main enzymes are monoamine oxidase B and dopamine beta hydroxylase (which converts dopamine to norepinephrine).<br><br>Rivastigmine is an acetylcholinesterase inhibitor used in the treatment of Alzheimer disease and dementia with Parkinson disease.<br><br>Trihexyphenidyl is an anticholinergic medication used in the treatment of dystonia.<br><br>Carbidopa reduces the peripheral destruction of L-dopa (a precursor to dopamine), but does not affect central nervous system dopamine metabolism
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Reference
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Bradleys NiCP, 7th edn, Ch. 96
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Option 1
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Is Correct (Option 1):
Rivastigmine
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Option 2
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Is Correct (Option 2):
Trihexyphenidyl
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Option 3
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Is Correct (Option 3):
Carbidopa
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Option 4
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Is Correct (Option 4):
Entacapone
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