Quiz Form

Question Date: 12/12/2023

Question: Which of the following is the most common cause of early-onset autosomal-dominant Alzheimer disease?

Options:

Amyloid precursor protein
Presenilin 1
Presenilin 2
ApoE4

Correct Answer: Presenilin 1

Explaination: Early-onset autosomal-dominant Alzheimer disease is caused by mutations in three main genes amyloid precursor protein, presenilin 1, and presenilin 2.<br>The presenilin 1 mutation being the most common mutation in early-onset disease.<br>The ApoE4 allele is common in autosomal-dominant late-onset Alzheimer disease but does not generally play a role in early-onset disease