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Question
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Which of the following is the most common cause of early-onset autosomal-dominant Alzheimer disease?
Explanation
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Early-onset autosomal-dominant Alzheimer disease is caused by mutations in three main genes amyloid precursor protein, presenilin 1, and presenilin 2.<br>The presenilin 1 mutation being the most common mutation in early-onset disease.<br>The ApoE4 allele is common in autosomal-dominant late-onset Alzheimer disease but does not generally play a role in early-onset disease
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Reference
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Bradleys NiCP, 7th edn, Ch. 95
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Option 1
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Is Correct (Option 1):
Amyloid precursor protein
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Option 2
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Is Correct (Option 2):
Presenilin 1
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Option 3
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Is Correct (Option 3):
Presenilin 2
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Option 4
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Is Correct (Option 4):
ApoE4
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