Quiz Form

Question Date: 09/01/2024

Question: Which of the following is not found in IBM?

Options:

• Anticytosolic 5 nucleotidase 1A is a potential biomarker
• Significant fat infiltration of Rectus femoris in MRI than other quadriceps muscle
• Fatty infiltration on MRI is more common than inflammation
• Flexor digitorum profundus is disproportionately weaker than other hand muscles

Correct Answer: Significant fat infiltration of Rectus femoris in MRI than other quadriceps muscle

Explaination: Anti cytosolic 5nucleotidase 1A(anti-NT5C1A) shows a specificity of greater than 90% in IBM<br>Fatty infiltration on MRI is more common than inflammation<br>Muscles most frequently involved include Flexor digitorum profundus of forearm and anterior compartment of thigh with sparing of rectus femoris and severe involvement of medial compartment of gastrocnemius<br>Early in the disease ,FDP is disproportionately weaker than other hand muscles (FDS , interossei and abductor pollicis muscles). Early FDP weakness can alert the diagnosis of IBM over other myositis/ALS.

Reference: Continuum : Muscle and NM junction Disorders(December 2022, Volume 28,no 6)Inclusion Body Myositis; Page no 1664-1667