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Question
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Which of the following is not found in IBM?
Explanation
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Anti cytosolic 5nucleotidase 1A(anti-NT5C1A) shows a specificity of greater than 90% in IBM<br>Fatty infiltration on MRI is more common than inflammation<br>Muscles most frequently involved include Flexor digitorum profundus of forearm and anterior compartment of thigh with sparing of rectus femoris and severe involvement of medial compartment of gastrocnemius<br>Early in the disease ,FDP is disproportionately weaker than other hand muscles (FDS , interossei and abductor pollicis muscles). Early FDP weakness can alert the diagnosis of IBM over other myositis/ALS.
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Reference
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Continuum : Muscle and NM junction Disorders(December 2022, Volume 28,no 6)Inclusion Body Myositis; Page no 1664-1667
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Option 1
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Is Correct (Option 1):
Anticytosolic 5 nucleotidase 1A is a potential biomarker
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Option 2
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Is Correct (Option 2):
Significant fat infiltration of Rectus femoris in MRI than other quadriceps muscle
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Option 3
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Is Correct (Option 3):
Fatty infiltration on MRI is more common than inflammation
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Option 4
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Is Correct (Option 4):
Flexor digitorum profundus is disproportionately weaker than other hand muscles
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