Quiz Form

Question Date: 10/01/2024

Question: Which of the following is the drug of choice in patient with RBD and clinical depression?

Options:

• Venlafaxine
• Duloxetine
• Bupropion
• Mirtazapine

Correct Answer: Bupropion

Explaination: The most common group of drugs inducing or worsening RBD are antidepressants<br>Most common agents are SSRI particularly Venlafaxine, SNRI like duloxetine followed by Tricyclic antidepressants<br>Mirtazapine and MAO inhibitors can also increase REM motor activity<br>Bupropion, dopaminergic/noradrenergic agonist does not induce RBD and is the choice for cases having associated depression ; however it does not have major anxiolytic effect<br>Beta blockers particularly propranolol also have been reported to induce RBD

Reference: Continuum : Sleep Neurology( August 2023, Volume 29,no 4)REM sleep behaviour disorder and other REM parasomnias Page 1101-1103