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Question
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Which of the following is the drug of choice in patient with RBD and clinical depression?
Explanation
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The most common group of drugs inducing or worsening RBD are antidepressants<br>Most common agents are SSRI particularly Venlafaxine, SNRI like duloxetine followed by Tricyclic antidepressants<br>Mirtazapine and MAO inhibitors can also increase REM motor activity<br>Bupropion, dopaminergic/noradrenergic agonist does not induce RBD and is the choice for cases having associated depression ; however it does not have major anxiolytic effect<br>Beta blockers particularly propranolol also have been reported to induce RBD
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Reference
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Continuum : Sleep Neurology( August 2023, Volume 29,no 4)REM sleep behaviour disorder and other REM parasomnias Page 1101-1103
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Option 1
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Is Correct (Option 1):
Venlafaxine
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Option 2
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Is Correct (Option 2):
Duloxetine
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Option 3
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Is Correct (Option 3):
Bupropion
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Option 4
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Is Correct (Option 4):
Mirtazapine
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