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Which of the following neurological manifestation is less likely to occur with POEMS syndrome?
Explanation
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Peripheral neuropathy- presenting feature in almost all cases Distal predominant painful sensorimotor demyelinating neuropathy mimicking CIDP 35-45% are wheelchair bound at presentation<br>Papilledema- main ocular manifestation ; rarely at presentation; disc swelling possibly due to increased vascular permeability, increased proteins.-<br>20-30% cases report venous/arterial thromboembolism <br>Venous(DVT, PE, Catheter associated DVT),Arterial(POVD,MI, Ischemic Stroke)<br>Ischemic stroke- present before or within 3 months of diagnosis. Half are multifocal- Mechanism- large vessel stenosis and thromboembolism. Prophylactic LMWH and single antiplatelet are suggested at diagnosis and continued until anti-plasma cell therapy is initiated and VEGF < 1000pg/ml
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Reference
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Continuum : Neurology of systemic diseases( June 2023, Volume 29,no 3) Hematologic Disorders and the Nervous System Page 838-839.
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Option 1
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Is Correct (Option 1):
Papilledema
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Option 2
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Is Correct (Option 2):
Acute Myelitis
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Option 3
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Is Correct (Option 3):
Demyelinating sensorimotor neuropathy
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Option 4
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Is Correct (Option 4):
Ischemic stroke
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