Quiz Form

Question Date: 01/02/2024

Question: Which of the following is not true regarding immune mediated neurological conditions associated with immune checkpoint inhibitors?

Options:

• Symptoms occur within first 6 cycles of treatment
• Necrotizing myositis may occur in combination or isolation
• De novo Myasthenia Gravis have no measurable autoantibodies
• Sensory predominant polyneuropathy may occur

Correct Answer: Sensory predominant polyneuropathy may occur

Explaination: Immune check point inhibitors can aggravate variety of immune mediated neurological conditions and severe complications occur in 1% of them<br>MG, necrotizing myositis, myocarditis or motor predominant polyneuropathy may occur in combination or isolation<br>Symptoms typically occur within 6 cycles of treatment<br>Prompt recognition is critical as symptoms evolve rapidly<br>Patient with de novo MG do not have measurable MG specific antibodies.

Reference: Continuum: Muscle and Neuromuscular Junction Disorders: Dec 2022, Vol 28, No 6: Diagnosis and management of Myasthenia Gravis: Page 1625