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Question
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Which of the following is not true regarding immune mediated neurological conditions associated with immune checkpoint inhibitors?
Explanation
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Immune check point inhibitors can aggravate variety of immune mediated neurological conditions and severe complications occur in 1% of them<br>MG, necrotizing myositis, myocarditis or motor predominant polyneuropathy may occur in combination or isolation<br>Symptoms typically occur within 6 cycles of treatment<br>Prompt recognition is critical as symptoms evolve rapidly<br>Patient with de novo MG do not have measurable MG specific antibodies.
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Reference
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Continuum: Muscle and Neuromuscular Junction Disorders: Dec 2022, Vol 28, No 6: Diagnosis and management of Myasthenia Gravis: Page 1625
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Option 1
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Is Correct (Option 1):
Symptoms occur within first 6 cycles of treatment
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Option 2
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Is Correct (Option 2):
Necrotizing myositis may occur in combination or isolation
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Option 3
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Is Correct (Option 3):
De novo Myasthenia Gravis have no measurable autoantibodies
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Option 4
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Is Correct (Option 4):
Sensory predominant polyneuropathy may occur
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