Quiz Form

Question Date: 16/02/2024

Question: Which of the following is the most serious potential adverse effect of mitoxantrone?

Options:

• Risk of seizure
• Risk of headache
• Risk of cardiomyopathy
• Risk of allergic reaction

Correct Answer: Risk of cardiomyopathy

Explaination: Among other adverse reactions, including gastrointestinal symptoms and immunosuppression, mitoxantrone may cause an irreversible cardiomyopathy. Therefore regular monitoring with echocardiograms or multigated acquisition scans is recommended, as well as a lifetime maximum dose of mitoxantrone due to cumulative risk. Seizure is a risk with dalfampridine, which is used to improve walking in patients with multiple sclerosis. Headache is a risk of beta-interferon therapy. Allergic reactions, mostly injection site specific, are seen with interferons. Progressive multifocal leukoencephalopathy has been associated with natalizumab, fingolimod, and dimethyl fumarate

Reference: ( Bradleys NiCP, 7th edn, Ch. 80, pp. 11591186)