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Question
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Which of the following is the most serious potential adverse effect of mitoxantrone?
Explanation
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Among other adverse reactions, including gastrointestinal symptoms and immunosuppression, mitoxantrone may cause an irreversible cardiomyopathy. Therefore regular monitoring with echocardiograms or multigated acquisition scans is recommended, as well as a lifetime maximum dose of mitoxantrone due to cumulative risk. Seizure is a risk with dalfampridine, which is used to improve walking in patients with multiple sclerosis. Headache is a risk of beta-interferon therapy. Allergic reactions, mostly injection site specific, are seen with interferons. Progressive multifocal leukoencephalopathy has been associated with natalizumab, fingolimod, and dimethyl fumarate
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Reference
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( Bradleys NiCP, 7th edn, Ch. 80, pp. 11591186)
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Option 1
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Is Correct (Option 1):
Risk of seizure
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Option 2
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Is Correct (Option 2):
Risk of headache
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Option 3
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Is Correct (Option 3):
Risk of cardiomyopathy
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Option 4
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Is Correct (Option 4):
Risk of allergic reaction
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