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Question
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Which of the following genetic tests should best detect a balanced chromosomal translocation?
Explanation
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Balanced chromosomal translocation can be detected by karyotype because the translocation changes the chromosome visually, but since no overall change occurs in the copy number of genomic material and only its location changes, chromosomal microarray is unable to detect balanced chromosomal translocations
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Reference
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CONTINUUM (MINNEAP MINN) 201824(1, CHILD NEUROLOGY)1836.
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Option 1
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Is Correct (Option 1):
Chromosomal microarray
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Option 2
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Is Correct (Option 2):
Whole exome sequencing
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Option 3
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Is Correct (Option 3):
Karyotype
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Option 4
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Is Correct (Option 4):
Multiplex PCR
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