Quiz Form

Question Date: 26/08/2023

Question: 67 year old male, presented with 2 month history of subacute onset progressive sleep disturbances, sleep apnea, stridor, myoclonus, cognitive impairment<br><br>MRI revealed following abnormality. Which of the following tests will you order?

Options:

• CSF 14-3-3
• Serum IgLON5
• Serum anti-TPO
• CSF NMDA antibody

Correct Answer: Serum IgLON5

Explaination: Patients with IgLON5 antibodies develop a characteristic sleep disorder preceded or accompanied by bulbar symptoms, gait abnormalities, oculomotor problems, cognitive decline featuring impaired executive function, visuospatial dysfunction, and episodic memory loss, movement disorders like orofacial and limb chorea, dystonia, hypomimia, bradykinesia, and myoclonus and hyperexcitability syndrome. MRI brain can be normal, show hypothalamus signalatrophy.

Reference: Gaig C, Graus F, Compta Y, Hgl B, Bataller L, Brggemann N, et al. Clinical manifestations of the anti-IgLON5 disease. Neurology Internet. 2017 May 2 cited 2022 Jun 1688(18)173643. Available from httpswww.ncbi.nlm.nih.govpmcarticlesPMC5409845