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Question
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Migraine like headache is not a feature of which neurological condition?
Explanation
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Migraine is seen in 75% of patients with CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leuko encephalopathy). The hallmark is migraine with prolonged and complex aura, and encephalopathy in 10%. Migraine like headache is also seen in MELAS (Mitochondrial encephalomyopathy, lactic acoidosis and stroke) and other mitochondrial disorders. Headache is common in sickle cell disease and 15% fulfill criteria of migraine. Other causes of headache include stroke, cerebral venous sinus thrombosis, bone infarcts in sickle cell crisis etc. Headache is not a feature of CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). They present with vascular dementia, alopecia and backache.
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Reference
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Saara Tikka et al. CADASIL and CARASIL. Brain Pathol. 201424(5)525-544.
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Option 1
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Is Correct (Option 1):
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
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Option 2
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Is Correct (Option 2):
MELAS
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Option 3
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Is Correct (Option 3):
Sickle cell disease
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Option 4
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Is Correct (Option 4):
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)
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